Micky van de Ven Double Ends The Toffees' Run at Brand New Home Ground
The Dutch defender became the first backline player to net twice in a Premier League match for Tottenham since the Belgian defender in March 2013.
Match summary
Micky Van de Ven heads into the net twice in first half
The home side's defender has goal disallowed after VAR review
Senegalese midfielder nets final goal in 89th minute
This loss is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven found the net twice as Tottenham extended their unbeaten run in away games in the top division and handed Everton their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after more than a century at the end of the previous campaign.
But Tottenham's leader Van de Ven struck twice from corners in the opening 45 minutes to place their strong form at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - nodded in a third to put the game to bed.
Jake O'Brien believed he had equalized the scores five minutes after Van de Ven's first goal, glancing a bullet header past the Spurs keeper from an set-piece.
Beto, in the meantime, missed a number of chances, while the Italian goalkeeper made a series of fine stops to guarantee the London club went five away games without defeat in the Premier League.
But the video assistant referee intervened, advising Craig Pawson to review the goal on the pitchside monitor and the referee ruled that Jack Grealish and the attacker were in offside positions and had interfered with the Spurs keeper.
This victory elevates Thomas Frank's side up to third in the Premier League, five points off local foes and leaders Arsenal.
The Merseyside club stay 14th and are six points clear of the drop zone.
Tottenham analysis: The defender excels in role at each end of the field
Following a drab midweek performance in the Champions League against Monaco, where they managed a mere two shots on target, Frank opted for the French striker up front instead of ex-Everton forward Richarlison.
The summer signing was failed to influence the game before being substituted for the substitute after an hour on the field, but it emerged he proved unnecessary in the final outcome.
Centre-back Van de Ven converted into an offensive threat to be reckoned with.
Tottenham's opening strike came from a cleverly executed set-piece play, with the midfielder directing the ball toward the six-yard box for an free Van de Ven to score.
And Ven de Ven - filling in as skipper in Cristian Romero's absence - added his next goal in first-half stoppage time as he outjumped the England keeper to head home.
The Dutchman was just as outstanding in defence, combining effectively with his defensive colleague as the duo dealt excellently with the 34 crosses sent their way by Everton.
Toffees breakdown: Toffees missing finishing touch
The club's recent stadium had been a fortress, but it seems the freshness may have faded slightly and supporters headed to the gates after Sarr's third for Tottenham.
The end in Everton's winning streak at home won't be a massive concern for the manager, but their attacking woes are.
Beto and the other striker - the Everton's pair of established strikers - had netted just a single goal between them before the weekend's match.
And they were unable to add to that miserable record on a damp and dreary evening on Merseyside.
The striker's form was summed up when he chose to overhead kick a golden opportunity from near the goal, despite having room and opportunity to reposition for a more conventional attempt that would have challenged the keeper.
The substitute, as well, failed to make an impact after coming on for the starter in the 65th minute.
It wasn't for a lack of chance. The majority of Everton's attacks came through the winger and Ndiaye, who tirelessly whipped dangerous balls into the Spurs box.
Upcoming fixtures for these two sides?
Everton: Moyes' men head to Sunderland in the top flight on early November at 8 PM.
Tottenham: The London club go to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup match against Newcastle.